The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression
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منابع مشابه
The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression.
Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3). However, VDR expression is lost during colon cancer progression, possibly causing unresponsiveness to 1,25(OH)2D3. Although several mechanisms responsible for resistance to 1,25(OH)2D3 action in different types of cancer had been reported, none explained the l...
متن کاملVitamin D and colon cancer.
The most active vitamin D metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), is a pleiotropic hormone with wide regulatory actions. Classically, vitamin D deficiency was known to alter calcium and phosphate metabolism and bone biology. In addition, recent epidemiological and experimental studies support the association of vitamin D deficiency with a large variety of human diseases, and ...
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The present study assesses the effects of two isoflavones, genistein and glycitein, and equol - a product of intestinal bacterial metabolism of dietary isoflavones, on vitamin D receptor (VDR) expression in an intestinal HT29 cell line. Genistein and glycitein significantly upregulated the VDR transcription and translation in HT29 cells. The effect of equol was less pronounced. Treating HT29 ce...
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Background and Objective: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Oxidative stress is one of the involved factors in CRC onset and progression. Recent examinations have revealed antioxidant characteristics of vitamin D. Given the vital role of this vitamin in balancing free radicals and antioxidant capacity, in this study we intended to review the association bet...
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Objective(s): The preclinical reports have shown that specific probiotics like Bifidobacterium bifidum (B. bifidum) and Lactobacillus acidophilus (L. acidophilus) can be applied as the biotherapeutic agents in the inhibition or therapy of colorectal cancer via the modification of gut bacteria. In the previous studies, we have assessed the impact of L. acidophilus and B...
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ژورنال
عنوان ژورنال: The Journal of Steroid Biochemistry and Molecular Biology
سال: 2010
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2010.01.014